Pulmonary Disease Clinical Trial
Official title:
A Study of Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in Patients With COPD in Different Stages of the Disease, and the Effect of Alcohol, Supplementary Oxygen and Zopiclone on These Changes.
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid
of carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2
and CO2. Patients with COPD is often seen to have co-morbidity with cardiac diseases.
Chronic systemic inflammation is seen in both COPD and cardiac diseases. The investigators
will investigate the sleep quality, CO2-retention, O2-saturation, cardiac arrythmias and
markers of inflammation in 120 patients with COPD in different stages of the disease. Our
hypotheses are:
- that the first signs of respiration failure type 2 is seen during sleep with alteration
of sleep patterns and greater and more long-lasting retention of CO2 in the blood
compared to those with a normal lung function
- that the use of alcohol, zopiclone or supplementary oxygen will make these differences
even greater
- that cardiac arrythmias correlates with hypoxemia
- that cardiac arrythmias and respiration failure correlates with degree of inflammation
n/a
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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