Pulmonary Arterial Hypertension Clinical Trial
Official title:
The Relationship Between Myocardial 18F-FDG Uptake and Right Ventricular Coupling Obtained by PET/MRI Hybrid Imaging in Patients With Pulmonary Arterial Hypertension.
Aim of the study is to compare novel parameters of right ventricle (RV) function from right heart catheterization (RHC) and magnetic resonance imaging (MRI) with PET-derived RV FDG uptake.
Objectives In pilot study investigators aimed to compare novel parameters of right ventricle
(RV) function from right heart catheterization (RHC) and magnetic resonance imaging (MRI)
with PET-derived RV FDG uptake.
Background Right ventricular (RV) function is a major determinant of survival in patients
with pulmonary arterial hypertension (PAH). Hemodynamic parameters like end-systolic
elastance (Ees), arterial elastance (Ea), pulmonary arterial compliance (PAC) and Ees/Ea
ratio have been shown to reflect RV function and prognosis in PAH. Increased RV
18F-fluoro-2-deoxyglucose (FDG) uptake in positron emission tomography (PET) was recently
associated with progressive RV dysfunction in these patients.
Methods Twenty-five stable PAH patients (49.92±15.94 years) and twelve healthy subjects
(control group, 44.75±13.51 years) had simultaneous PET and MRI scans performed. FDG was used
as a tracer and its uptake was presented as a standardized uptake value (SUV) for both left
(LV) and right ventricle.
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