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Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension — ERA-PAH  

Pulmonary Arterial Hypertension Clinical Trial

Official title:
Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension

Clinical Trial Summary

The main purpose of this clinical trial is to examine the feasibility and effects of fulvestrant in post-menopausal women with pulmonary arterial hypertension (PAH). The study will evaluate how well the drug is tolerated. The study will evaluate changes in circulating hematopoietic progenitor cells, plasma hormone levels, NT-proBNP, and other plasma biomarkers after the administration of fulvestrant. Changes in tricuspid annular plane systolic excursion, stroke volume index, right ventricular fractional area change, and other echo parameters after fulvestrant administration will be evaluated as well as changes in distance walked in six minutes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02911844
Study type Interventional
Source University of Pennsylvania
Contact
Status Completed
Phase Phase 2
Start date April 10, 2017
Completion date December 5, 2018
View Details
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