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Crossover Study From Macitentan or Bosentan Over to Ambrisentan — Letairis  

Pulmonary Arterial Hypertension Clinical Trial

Official title:
A Safety and Clinical Efficacy Study Measuring Echocardiographic Composite Comparing Ambrisentan (Letairis®) After a Switch From Bosentan (Tracleer®) or Macintentan (Opsumit®) in Treatment of Pulmonary Arterial Hypertension (PAH)

Clinical Trial Summary

The purpose of this study is to learn more about the safety and effects of switching treatments from bosentan (Tracleer) or macientan (Opsumit) to ambrisentan (Letairis) over 24 weeks in subjects with Connective Tissue Disease associated Pulmonary Arterial Hypertension (CTD-PAH).

Clinical Trial Description

The study will consist of a group of subjects who have been on bosentan for at least three months and a group that has been on macitentan for at least three months. Both groups will be switched to Letairis 5mg daily after the bosentan or macitentan therapy for three months and then increased to a dose of Letairis 10mg daily at week 4 if well tolerated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02885012
Study type Interventional
Source Medical University of South Carolina
Contact
Status Terminated
Phase Phase 4
Start date June 2016
Completion date July 7, 2017
View Details
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