PTSD Clinical Trial - Glecaprevir/Pibrentasvir for the Treatment of PTSD

Status Recruiting

Clinical Trial Summary

An open-label pilot study to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV).

Clinical Trial Description

To perform an open-label pilot study (N=10) to further investigate glecaprevir/pibrentasvir (GLE/PIB), a direct acting antiviral (DAA) that has been associated with posttraumatic stress disorder (PTSD) symptom improvement when prescribed for the treatment of chronic hepatitis C viral infection (HCV). The specific research described in this proposal is intended to pilot GLE/PIB for N=10 patients with PTSD in the absence of HCV. Primary Aims: Aim 1: Determine the feasibility of testing GLE/PIB for PTSD symptoms. Aim 2: Determine the feasibility of testing GLE/PIB for functioning among patients with PTSD. Aim 3: Assess the safety and tolerability of GLE/PIB treatment for patients with PTSD in the absence of HCV. Exploratory Aim: Investigate the possible biological mechanism of GLE/PIB for PTSD via blood bio-marker analyses. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05446857
Study type	Interventional
Source	White River Junction Veterans Affairs Medical Center
Contact	Bradley V Watts, MD, MPH
Phone	802-295-9363
Email	bradley.watts@va.gov
Status	Recruiting
Phase	Phase 2/Phase 3
Start date	April 1, 2023
Completion date	June 30, 2024

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