PTSD Clinical Trial
Official title:
A Randomized, Placebo-Controlled Trial of Quetiapine (Seroquel) Monotherapy in the Treatment of PTSD
The purpose of the study is to determine if quetiapine is effective in the treatment of PTSD.
Objective: To assess the impact of quetiapine on core PTSD symptoms and associated
psychiatric comorbidity including depressive and positive and negative psychotic symptoms.
Research Design: 12-week, double-blind, placebo-controlled, randomized, fixed-flexible dose
trial of quetiapine monotherapy.
Intervention: Eligible patients will be randomized to receive quetiapine starting at 25 mg
daily or matching placebo. Dose adjustments (to a minimum of 50 mg or a maximum of 800 mg),
will be made at the investigator's discretion and according to patient's clinical response.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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