V3: Vancouver-Victoria Valacyclovir Trial for Early Psychosis

Status Completed

Clinical Trial Summary

This is an 18 week (2 weeks run-in, 16 weeks double blind) trial, to determine if an antiviral drug, valacyclovir (Valtrex) is helpful in treating the symptoms of psychosis, a form of a mental disorder.

Clinical Trial Description

There is evidence that some of the symptoms of psychosis may be related to past infection with common viruses.

Researchers are looking to recruit a total of 100 subjects with evidence in the past, of exposure to at least 1 of 3 viruses. The viruses include herpes type 1 (HSV-1, which causes cold sores of the lip and has affected about 6/10 people in Vancouver), herpes type 2 (HSV-2 which causes genital sores, and has affected less than 1/10 people in Vancouver) and cytomegalovirus (CMV, which causes few symptoms but has affected 8/10 people in Vancouver). People who have been infected with these viruses in the past develop antibodies in the blood. The antibodies can be measured in blood, and are a test of whether or not there was infection in the past, and possibly affecting the symptoms of psychosis. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00175513
Study type	Interventional
Source	University of British Columbia
Contact
Status	Completed
Phase	Phase 2
Start date	September 2005
Completion date	September 2009

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04929938` - Application of UP for Transdiagnostic Treatment of Emotional Disorders for UHR for Psychosis Patients	N/A
Recruiting	`NCT05863572` - Strengthening Care in Collaboration With People With Lived Experience of Psychosis in Uganda	N/A
Completed	`NCT04277585` - Improving Access to Early Psychosis Coordinated Specialty Care	N/A
Recruiting	`NCT06197048` - Effect of Nutritional Counseling on Anthropometry and Biomarkers in Patients Diagnosed With Schizophrenia/Psychosis or Bipolar Affective Disorder	N/A
Completed	`NCT04284813` - Families With Substance Use and Psychosis: A Pilot Study	N/A
Terminated	`NCT04404712` - FAAH Availability in Psychiatric Disorders: A PET Study	Early Phase 1
Recruiting	`NCT05769933` - Bridging Gaps in the Neuroimaging Puzzle: New Ways to Image Brain Anatomy and Function in Health and Disease Using Electroencephalography and 7 Tesla Magnetic Resonance Imaging
Recruiting	`NCT04298450` - ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis Intervention	N/A
Not yet recruiting	`NCT05558332` - Youth Nominated Support Team	N/A
Not yet recruiting	`NCT05358457` - Pilot Study to Evaluate the Effectiveness of Online Familiar Metacognitive Training (MCTf)	N/A
Not yet recruiting	`NCT03807388` - ReMindCare App for Patients From First Episode of Psychosis Unit.	N/A
Completed	`NCT02895269` - COllaborative Shared Care to IMprove Psychosis Outcome	N/A
Recruiting	`NCT02622048` - Understanding and Helping Families: Parents With Psychosis	N/A
Completed	`NCT02653729` - Cbt for Psychosis and Affect on Psychosis Symptoms	Phase 2
Completed	`NCT02531243` - Computer-Aided Learning for Managing Stress	N/A
Completed	`NCT02733575` - Compassion Focused Therapy for Distressing Experiences	N/A
Not yet recruiting	`NCT02244970` - Mindfulness RCT for Early Psychosis	N/A
Enrolling by invitation	`NCT01364818` - Brain Connectivity in Neurodevelopmental Disorders in Response to Treatment	N/A
Withdrawn	`NCT00786318` - Ziprasidone vs Standard Therapy for Agitated Patients in the ED	Phase 4
Recruiting	`NCT00722163` - A Randomized Controlled Trial of Individual Therapy for First Episode Psychosis	Phase 0