LOXL1 Polymorphism in Pseudoexfoliation Syndrome

Pseudoexfoliation Syndrome Clinical Trial

Official title:

Evaluation of LOXL1 Polymorphism in Pseudoexfoliation Syndrome in the Korean Population

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01515735
• Other study ID #: 2011-06-035
• Status: Recruiting
• Phase: N/A
• First received: January 18, 2012
• Last updated: January 23, 2012
• Start date: December 2011
• Est. completion date: December 2012

Study information

• Verified date: January 2012
• Source: Samsung Medical Center
• Contact: Changwon Kee, M.D., Ph.D.
• Phone: 82-2-3410-3564
• Email: ckee[@]skku.edu
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, Genotypes of lysyl oxidase-like 1 gene were analyzed by direct sequencing.

Description:

To evaluate the association profiles of the lysyl oxidase-like 1 gene polymorphisms with pseudoexfoliation syndrome in the Korean population, peripheral blood sampling will be done from the patients with pseudoexfoliation.

And genotypes of the three single nucleotide polymorphisms of lysyl oxidase-like 1 gene , rs1048661, rs3825942, rs2165241 were analyzed by direct sequencing.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: December 2012
• Est. primary completion date: December 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years to 70 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of Pseudoexfoliation

Exclusion Criteria:

• medical condition that peripheral blood sampling cannot be done

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Exfoliation Syndrome
• Pseudoexfoliation Syndrome
• Syndrome

Locations

Country	Name	City	State
Korea, Republic of	Samsung medical center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Samsung Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (2)

Fuse N, Miyazawa A, Nakazawa T, Mengkegale M, Otomo T, Nishida K. Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese. Mol Vis. 2008 Jul 21;14:1338-43. — View Citation

Mori K, Imai K, Matsuda A, Ikeda Y, Naruse S, Hitora-Takeshita H, Nakano M, Taniguchi T, Omi N, Tashiro K, Kinoshita S. LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population. Mol Vis. 2008 Jun 5;14:1037-40. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Genotypes of the three single nucleotide polymorphisms of LOXL1 (rs1048661, rs3825942, rs2165241)	Genotypes of the three single nucleotide polymorphisms of LOXL1 were analyzed by direct sequencing, after obtained from the peripheral blood sampling from patients.	about 1 year (when all patients were recruited)	Yes