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Clinical Trial Summary

The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic peripheral neuropathy. Diabetic neuropathy is the most frequent chronic complication in adults with DT1 and rarely appears in childhood. Nevertheless, cases of acute mononeuritis have been described at the time of diagnosis of DT1. According to recent reports several biomarkers, including proteomic analysis, have been proposed for the early detection of peripheral neuropathy in children and young adults with T1DM. In the present study the researchers will attempt to investigate the role of biomarkers with targeted proteomic analysis in the plasma of children with DT1 in combination with an electrophysiological study, which includes a nerve conduction study, to detect early diabetic peripheral neuropathy, before the appearance of clinical manifestations.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT04257877
Study type Observational
Source Aristotle University Of Thessaloniki
Contact Assimina Galli-Tsinopoulou, MD,PhD
Phone +302310991537
Email agalli@auth.gr
Status Recruiting
Phase
Start date November 20, 2018
Completion date July 20, 2024

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