Prostatic Neoplasm Clinical Trial
Official title:
Evaluation of Planning Computed Tomography Scan and Magnetic Resonance Imaging Simulator Scan Co-Registration for Delineation of Gross Tumour Volume in Radiotherapy Treatment of Localized Prostate Cancer
The target volume in prostate cancer radiotherapy typically consists of the entire prostate
gland which is localized by contours drawn on axial computed tomography (CT) radiation
planning images. Compared with CT, magnetic resonance (MR) can provide better definition of
the prostate gland with respect to the surrounding tissues and the use of multi-plannar
reconstruction avoids the problem of partial volume averaging inherent in CT. CT has been
shown to significantly overestimate the volume of the gland using the MR-defined prostate
volume as the gold standard. Co-registration of MR and CT datasets, matched on fixed bony
landmarks, has enabled radiation planning using a MR-defined clinical target volumes,
combined with CT-based electron density information necessary for radiation treatment
planning.
Rationale and Hypothesis:
Co-registration may allow better delineation of tumour volumes in prostate cancer. This
investigation is a fesibility study designed to evaluate and optimize imaging parameters and
co-registration techniques for CT planning and MRI Simulator.
n/a
Time Perspective: Prospective
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