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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00252460
Other study ID # UHN REB 03-0601-CE
Secondary ID
Status Completed
Phase Phase 1
First received November 9, 2005
Last updated March 24, 2016
Start date November 2003
Est. completion date November 2010

Study information

Verified date March 2016
Source University Health Network, Toronto
Contact n/a
Is FDA regulated No
Health authority Canada: Ethics Review Committee
Study type Observational

Clinical Trial Summary

The target volume in prostate cancer radiotherapy typically consists of the entire prostate gland which is localized by contours drawn on axial computed tomography (CT) radiation planning images. Compared with CT, magnetic resonance (MR) can provide better definition of the prostate gland with respect to the surrounding tissues and the use of multi-plannar reconstruction avoids the problem of partial volume averaging inherent in CT. CT has been shown to significantly overestimate the volume of the gland using the MR-defined prostate volume as the gold standard. Co-registration of MR and CT datasets, matched on fixed bony landmarks, has enabled radiation planning using a MR-defined clinical target volumes, combined with CT-based electron density information necessary for radiation treatment planning.

Rationale and Hypothesis:

Co-registration may allow better delineation of tumour volumes in prostate cancer. This investigation is a fesibility study designed to evaluate and optimize imaging parameters and co-registration techniques for CT planning and MRI Simulator.


Recruitment information / eligibility

Status Completed
Enrollment 31
Est. completion date November 2010
Est. primary completion date November 2010
Accepts healthy volunteers No
Gender Male
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Histological confirmation of Prostate Adenocarcinoma

- Undergoing RT with fiducial markers, IMRT or Escalated Dose Conformal RT

Exclusion Criteria:

- Contraindication for MRI

Study Design

Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Device:
Computed Tomography Scan and Magnetic Resonance Imaging


Locations

Country Name City State
Canada University Health Network Toronto Ontario

Sponsors (2)

Lead Sponsor Collaborator
University Health Network, Toronto Princess Margaret Hospital, Canada

Country where clinical trial is conducted

Canada, 

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