Prostate Neoplasm Clinical Trial
Official title:
Diagnostic Performance of 68Ga-PSMA PET/MRI in Suspicious Biopsy-naive Prostate Cancer Patients With Favorable Lesion on PET But Unfavorable on MRI for Primary Prostate Cancer Detection: a Pilot Study
This perspective cohort study aims to assess the detection rate of prostate cancer through prostate biopsy within suspicious patients harboring unfavorable multiparametric MRI but favorable 68Ga-PSMA PET/MRI who have had no prior prostate biopsy.
Multiparametric MRI (MpMRI) is currently regarded as the best imaging method to noninvasively
identify and characterize prostate cancer (PCa) with the Prostate Imaging Reporting and Data
System (PI-RADS) v2. However, there are diagnostic difficulties for suspicious patients with
PI-RADS score 3 and not all PCa are equivalently visible on mpMRI. For such patients, other
alternative imaging techniques are required to properly characterize and detect PCa.
It has been widely reported that 68Ga-PSMA PET imaging offers excellent performance in
detecting primary PCa and is able to noninvasively characterize the aggressiveness of PCa.
Recently, integrated PET/MRI, which combines the strengths of both modalities, has been shown
to have great potential for influencing clinical practice by providing a more certain map of
localized PCa to aid targeted biopsies and therapy.
This perspective cohort study aims to assess the detection rate of PCa through prostate
biopsy within suspicious patients harboring unfavorable mpMRI but favorable 68Ga-PSMA PET/MRI
who have had no prior prostate biopsy.
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