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Clinical Trial Summary

To determine efficacy, safety and tolerabiltiy of topically applied BZ371A in patients that experienced RP, in combination with daily tadalafil compared to placebo.


Clinical Trial Description

Prostate cancer remains one of the most prevalent cancer in men. For its treatment, recent technological advances demonstrate that the most effective treatment is the Radical Prostatectomy (RP) procedure. However, although curative for Prostate Cancer, can result in damage to the cavernosal nerves. The cavernosal autonomic nerves travel posterolaterally to the prostate to enter the penis and regulate blood flow and hence erection. Thus, damage caused by RP will affect NO tissue release and blood flow regulation, causing erectile dysfunction. BZ371A has the ability to restore local blood flow regulation by a new and innovative mechanism of action and, therefore, has potential to be a supportive therapy for RP patients (restoring the erectile function). Thus, this study aims to evaluate efficacy, safety and tolerabilty of BZ371A on the recovery of erectile function of patients that were underwent Radical Prostatectomy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05558007
Study type Interventional
Source Biozeus Biopharmaceutical S.A.
Contact Camilla NR Trindade, PhD
Phone +55(21)2523-9089
Email camilla.nunes@biozeus.com.br
Status Recruiting
Phase Phase 2
Start date November 22, 2023
Completion date September 2024

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