Prostate Cancer Clinical Trial
Official title:
Abiraterone Dose De-Escalation Study: A Prospective Study Evaluating Decreasing Dosing Regimens of Abiraterone 500 mg in Men With Prostate Cancer to Find Lowest Recommended Dose.
Verified date | January 2024 |
Source | University of Chicago |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Doctors leading this study plan to collect new information about the lowest effective dose of abiraterone acetate in study participants with prostate cancer who are taking abiraterone in combination with prednisone for the first time. The duration of this study will be about 3 months (12 weeks). How long you stay on abiraterone, and at what dose after completion of the 12 weeks of study drug administration, will be up to you and your treating physician.
Status | Active, not recruiting |
Enrollment | 50 |
Est. completion date | November 1, 2025 |
Est. primary completion date | July 1, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Histologically or cytologically confirmed prostate cancer with plans to initiate abiraterone acetate - Have never received prior abiraterone or other androgen receptor modulators, including enzalutamide, apalutamide, or darolutamide. - Must have a baseline DHEA-S level of >20 mg/dL (in order to adequately assess DHEA-S response) - A minimum washout of 28 days for any other anticancer therapy other than medical or surgical castration, prior to first dose of study drug is required. - Any other radiotherapy or radionuclide require 28-day washout prior to first dose of study drug. - Denosumab or zoledronic acid are allowed. - Eastern Cooperative Oncology Group performance status = 2 (Appendix A). - Participants must have normal hepatic function as defined by clinical lab values set by the study doctor/research team. - Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: - Therapy with other hormonal therapy, including any dose of megestrol acetate (Megace), finasteride (Proscar), dutasteride (Avodart), or any herbal product known to decrease Prostate-Specific Antigen levels or any systemic corticosteroid (other than prednisone =10mg/day) within 4 weeks prior to first dose of study drug. - Inability to swallow capsules or known gastrointestinal malabsorption. - Blood pressure that is not controlled despite > 2 oral agents (SBP >160 and DBP >90 documented during the screening period with no subsequent blood pressure readings <160/100). - Serum K+ < 3.5 mmoL/L. Patients with a K+ < 3.5 mmoL/L are required to have a documented subsequent K+ >3.5 prior to enrollment to be eligible. - Serious intercurrent infections or non-malignant medical illnesses that are uncontrolled. - Active psychiatric illness/social situations that would limit compliance with protocol requirements. - Serious heart issues/congestive heart failure as assessed by New York Heart Association's definition of class II, class III, or IV congestive heart failure. - Taking other medications or drugs with strong inhibitors or inducers of CYP3A4 (See Section 8.12 below for list of strong inhibitor or inducers) due to concerning possible drug-drug interactions with abiraterone. |
Country | Name | City | State |
---|---|---|---|
United States | University of Chicago Medicine Comprehensive Cancer Center | Chicago | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Chicago |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in DHEA-S Levels Among Participants at 4 Weeks | Efficacy of different dosing regimens of abiraterone 500 mg as assessed by decrease/reduction in serum dihydroepiadrosterone sulfate (DHEA-S) levels among participants at 4 weeks. | 4 weeks | |
Secondary | Change in Prostate-Specific Antigen (PSA) Levels of Participants at 12 Weeks | The effects of different dosing regimens of abiraterone 500 mg on serum as assessed by a reduction/decline in Prostate-Specific Antigen (PSA) levels (a 50% decline in PSA from baseline) at 12 weeks. | 12 weeks | |
Secondary | Rate of Adverse Events Reported Among Participants in Different Abiraterone Dosing Regimen Groups | Rate of adverse events reported among participants taking abiraterone 500 mg in different dosing groups as assessed by the Common Terminology Criteria for Adverse Events version 5. | 12 weeks |
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