Prostate Cancer Clinical Trial
Official title:
A Study of 18F-AlF-NOTA-Neurotensin PET/CT for Imaging Prostate Cancer
The aim of this study is to investigate the clinical value of [18F]aluminum fluoride-1,4,7-triazacyclononane-1,4,7-triacetic acid-neurotensin(18F-AlF-NOTA-neurotensin)positron emission tomography / computed tomography (PET/CT) in patients with prostate cancer (PCa).
Status | Recruiting |
Enrollment | 65 |
Est. completion date | December 30, 2020 |
Est. primary completion date | December 30, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. Histologically and/or clinically confirmed and/or suspicious of PCa. 2. Signed informed consent. Exclusion Criteria: Claustrophobia (unable to accept PET/CT scanning) |
Country | Name | City | State |
---|---|---|---|
China | Department of PET Center,Xiangya Hospital,Central South University | Changsha | China, Hunan |
Lead Sponsor | Collaborator |
---|---|
Xiangya Hospital of Central South University |
China,
Deng H, Wang H, Wang M, Li Z, Wu Z. Synthesis and Evaluation of 64Cu-DOTA-NT-Cy5.5 as a Dual-Modality PET/Fluorescence Probe to Image Neurotensin Receptor-Positive Tumor. Mol Pharm. 2015 Aug 3;12(8):3054-61. doi: 10.1021/acs.molpharmaceut.5b00325. Epub 2015 Jul 21. — View Citation
Maschauer S, Einsiedel J, Hübner H, Gmeiner P, Prante O. (18)F- and (68)Ga-Labeled Neurotensin Peptides for PET Imaging of Neurotensin Receptor 1. J Med Chem. 2016 Jul 14;59(13):6480-92. doi: 10.1021/acs.jmedchem.6b00675. Epub 2016 Jun 30. — View Citation
Wu Z, Li L, Liu S, Yakushijin F, Yakushijin K, Horne D, Conti PS, Li Z, Kandeel F, Shively JE. Facile Preparation of a Thiol-Reactive (18)F-Labeling Agent and Synthesis of (18)F-DEG-VS-NT for PET Imaging of a Neurotensin Receptor-Positive Tumor. J Nucl Med. 2014 Jul;55(7):1178-84. doi: 10.2967/jnumed.114.137489. Epub 2014 May 22. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 18F-AlF-NOTA-neurotensin PET/CT imaging of patients with Prostate Cancer | The radioligand 18F-AlF-NOTA-neurotensin can be used to visualize prostate cancer | 12 months | |
Secondary | 18F-AlF-NOTA-neurotensin PET/CT prognostic factor for overall and disease specific survival | The standard uptake value (SUV) of the 18F-AlF-NOTA-neurotensin in prostate cancer lesions is associated with Gleason score, staging and risk stratification of prostate cancer. SUV (g/mL)=Cimg / (ID/BW) ; Cimg is the prostate cancer pixel intensities of a calibrated PET image (MBq/ml), ID is the injected dose or injected radioactivity (MBq),BW is the body weight (g) . Gleason score of a prostate biopsy or radical prostatectomy. |
24 months |
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