Prostate Cancer Clinical Trial
Official title:
Investigating and Characterizing the Immune Response to Prostate Cancer
This study is a clinical study to investigate and characterize the immune response profile to four different prostate cancer treatments (total cryotherapy, focal cryotherapy, Cyberknife SBRT, and radical prostatectomy) in patients with localized prostate cancer.
The immune system plays an important role in cancer, and there is evidence that different
types of cancer treatment can elicit different responses from the body's immune system. This
study is designed to look at immune markers in the blood and urine of patients undergoing
four different types of prostate cancer treatment and compare the differences.
Patients who have elected Total Cryotherapy (freezing of the entire prostate), focal
cryotherapy (freezing only the side of the prostate affected by cancer), Cyberknife
stereotactic body radiation therapy (SBRT) and Radical Prostatectomy (removal of the entire
prostate) for the treatment of their prostate cancer will be eligible to participate in this
study. The study is expected to enroll 40 patients, 10 patients per treatment group. The
study includes a screening visit during which the subject will provide informed consent, and
provide a blood sample and a urine sample. At 2-3 weeks following their scheduled treatment,
they will again provide another blood and urine sample. At their regularly scheduled follow
up at 3 months, they will again provide another blood and urine sample. These samples are
collected for research purposes only, and the costs will be covered by the study grant
account, without any additional cost to the patient.
The investigators have determined that this study presents no more than minimal risk to
patients due to the minimal risks involved with a blood draw and urine specimen collection.
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