Hyperpolarized Carbon-13 Imaging of Metastatic Prostate Cancer

Prostate Cancer Clinical Trial

Official title:

Hyperpolarized Carbon-13 Imaging of Metastatic Prostate Cancer

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02844647
• Other study ID #: 432-2015
• Status: Terminated
• Phase: Phase 1
• Start date: December 15, 2016
• Est. completion date: March 23, 2023

Study information

• Verified date: March 2023
• Source: Sunnybrook Health Sciences Centre
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A pilot study with a group of up to 10 men with CRPC about to embark on a 6-month course of treatment with radium 223. Study participants will undergo anatomical MR imaging combined with the new hyperpolarized MRI (1 hour exam) prior to treatment.

Description:

"Hyperpolarization" of low natural abundance species such as 13C, offers the potential of extracting metabolic information by real-time imaging of biochemical reactions within the body. In this project, the investigators focus on prostate cancer, specifically late-stage disease, as management of these patients would benefit from a new imaging method that enables improved therapy selection, planning and monitoring.

For imaging the lactate distribution in bone-metastatic prostate cancer, 3D coverage of a large field-of-view is required in order to cover the vertebral column (the most common site of metastases). To enable this, the investigators have developed methods using a large-volume transmitter and multi-channel receiver system for 3-dimensional 13C metabolic imaging in these patients. The image resolution and encoding matrix were tailored to the required 3D coverage of the vertebral column.

At the end of this study, the investigators will have the methodology, hardware and clinical-research workflow needed to evaluate 13C-lactate imaging as a new tool to help patients with metastatic prostate cancer. The investigators would be the first in the world to apply 13C metabolic MRI to bone metastases. Although the investigators propose to study patients who are starting a 6-month course of treatment with radium 223, in this project, this proof-of-concept study may also lead to a larger clinical trial at different points in the treatment pathway, such as prior to deciding between treatment with cytotoxic agents versus drugs that target the androgen axis such as abiraterone.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 2
• Est. completion date: March 23, 2023
• Est. primary completion date: March 23, 2023
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Men with bone-metastatic CRPC before starting the first dose of radium 223 therapy

• Laboratory requirements:

• Absolute neutrophil count (ANC) = 1.5 x 109/L

• Platelet count = 100 x109/L

• Hemoglobin = 10.0 g/dL (100 g/L; 6.2 mmol/L)

• Total bilirubin level = 1.5 institutional upper limit of normal (ULN)

• ASAT and ALAT = 2.5 ULN

• • Creatinine = 1.5 ULN

• Albumin >25 g/L

• Eastern Cooperative Oncology Group Status of 0 or 1

Exclusion Criteria:

• Unable to give valid informed consent

• Contraindication for MRI as per Sunnybrook MRI questionnaire (Appendix 1).

• Claustrophobia

• Body mass index of less than 18.5 or greater than 32

• Congestive heart failure, a past or present medical history of clinically significant electrocardiogram (EKG) abnormalities, which may include QT prolongation, a family history of prolonged QT interval syndrome, or a myocardial infarction (MI) within the past 12 months with ensuing unstable EKG, or ongoing acute or chronic pulmonary bronchospastic disease, including a history of chronic obstructive pulmonary disease or asthma, with an exacerbation within the past year

Related Conditions & MeSH terms

• Prostate Cancer
• Prostatic Neoplasms

Intervention

Other:
• Hyperpolarized Pyruvate (13C)
MRI contrast agent

Locations

Country	Name	City	State
Canada	Sunnybrook Health Sciences Centre	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Sunnybrook Health Sciences Centre

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Images of lactate, bicarbonate and pyruvate in patients with bone-metastatic CRPC measured by MRI		1 year