Prostate Cancer Clinical Trial
Official title:
CEUS Targeted Biopsies Compared to mpMRI Targeted and Systematic Biopsies for the Detection of Prostate Cancer
The current standard for Prostate Cancer (PCa) detection remains taking 10-12 systematic
biopsies of the prostate. This approach leads to overdiagnosis of insignificant PCa on the
one hand and underdiagnosis and undergrading of significant PCa on the other. multiparametric
Magnetic Resonance Imaging (mpMRI) has seen an increasing uptake in the clinics for biopsy
targeting, but the value in biopsy naive patients remains controversial. With Contrast
Enhanced UltraSound (CEUS) cancer induced neovascularisation can be visualised with the
potential to improve ultrasound imaging for prostate cancer detection and localisation
significantly. The past years numerous studies have been performed with CEUS, all basing
their results on subjective judgement of the investigator. To overcome these difficulties
CEUS quantification techniques have been used with encouraging first results. These imaging
techniques have been proposed to improve the yield of prostate biopsies and possibly
replacing systematic biopsies.
In this trial mpMRI imaging and CEUS + quantification are performed before primary biopsy.
Using a fusion device, targeted biopsies are taken from predefined MRI lesions and CEUS
lesions, together with standard systematic biopsies in the same patients by separate blinded
clinicians. The main outcome measure is the per-patient (significant) prostate cancer
detection rate for each of the biopsy regimens.
n/a
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