Prostate Cancer Clinical Trial
Official title:
Changes in Bladder Function After Surgery and Radiation Therapy for Prostate Cancer
The purpose of this study is to describe the urinary morbidity as a result surgery and
radiation therapy, in patients treated for prostate cancer.
All the patients will undergo a Urodynamic examination to verify the grade of Urinary
morbidity.
Introduction:
There is a little knowledge on long-term urinary morbidity in patients treated with radical
prostatectomy (RP) and salvage radiotherapy (SRT). Both treatments are potentially curative
for localized prostate cancer (PC). Improved long-term survival makes the awareness of late
effects from radiotherapy important.
Purpose:
The purpose of this study was to access, late urinary morbidity in patients treated with
SRT. The patients included in this study will have an urodynamic examination. The results
from the urodynamic examination will help us with a better understanding of the different
symptoms and their grade, after treatment with RP and SRT because of PC.
Materials and methods:
A total of 67 patients will be invited to participate in this urodynamic study. The patients
will undergo a urodynamic examination, included biomechanical examination of urethra. The
examination is a standard procedure at the department of Urology, Aarhus University
hospital, Denmark.
The patients will, in relation to the urodynamics, have taken two blood samples. The blood
samples, will later on, be used to detect some of the genetic reasons for morbidity after
radiotherapy.
Endpoint:
The primary endpoint is the outcome of different parameters as a result of the urodynamic
examination.
Perspective:
The perspective of this study is to help understanding the efficacy og morbidity of salvage
radiotherapy. The investigators hope to get a better understanding of the mechanisms related
to urinary morbidity.
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Observational Model: Cohort, Time Perspective: Prospective
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