Prostate Cancer Clinical Trial
Official title:
Post-prostatectomy Daily Target Guided Radiotherapy Using Real-Time, State-of-the-Art Motion Tracking With the Calypso 4D Localization System: A Feasibility Study
This study will evaluate the daily use of a unique daily organ tracking system on target
localization in patients treated with radiation therapy after radical prostatectomy for
prostate cancer.
Improved coverage of the target volume with radiotherapy could result in improved cancer
control rates and decreased coverage of surrounding structures potentially decreasing
treatment toxicity.
This prospective study evaluates the clinical utility of a novel real-time localization
system of the prostate bed during adjuvant or salvage radiotherapy after radical
prostatectomy. This study will also determine positioning errors using daily cone-beam
computed tomography in patients set up with the Calypso 4D Localization System. Subjects
will have Beacon® Transponders implanted into the prostate bed. The Calypso 4D Localization
System will localize the position of the prostate bed. Cone beam CT will be used daily to
measure inter-transponder distance. The Calypso system will also track the prostate bed
position in real time during the entire radiation treatment. The treatments will be adjusted
as required to ensure accurate treatment of the clinical target volume. The time of, the
number, and extent of adjustments will be recorded for analysis.
Daily cone-beam computed tomography images will also be retrospectively analyzed to assess
for adequate target coverage. The analysis will be performed retrospectively through manual
3-D registration of the cone-beam CT dataset with the treatment planning CT scan. This
information will determine the margins necessary for the PTV using the Calypso 4D
Localization System and potentially may allow a reduction in the PTV volumes on future
studies.
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Observational Model: Cohort, Time Perspective: Prospective
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