Prostate Cancer Clinical Trial
Official title:
Evaluation of the Response to Irradiation With MR-Spectroscopy for Localised Prostate Cancer Patients (The ERIS Trial)
Context:
Prostate cancer is the most common non-cutaneous cancer and the second most common cause of
cancer-related deaths in European and North-American men.
After external radiotherapy or brachytherapy, the Prostate Specific Antigen (PSA) value is
often fluctuating and PSA nadir may only be reached after 2 years or more and may remain
detectable several years after the completion of radiation. Moreover, PSA bounces and blips
render patients and physicians very anxious about any possibility of a relapse. In this
context, biomarkers that could predict the response to radiation earlier than PSA for
patients with prostate cancer appear long overdue.
Magnetic Resonance Spectroscopy at 3 Tesla without endorectal coil is a non invasive
procedure which allows quantification of metabolites such as Choline, Creatine, Polyamines
and Citrate within the prostate gland.
Objectives:
The investigators are conducting a French prospective study on the Evaluation of the
Response to Irradiation with MR Spectroscopy (ERIS). Their purpose is to monitor the early
response of radiation with 3D MR Spectroscopy during the first year after completion of
radiation and its impact on biochemical control. Therefore, the ERIS trial aims to
investigate whether or not there could be a correlation between the time course of PSA and
that of Choline and Citrate.
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