Prostate Cancer Clinical Trial
Official title:
Conventional and Contrast-Assisted Frequency Functional Ultrasound for Imaging of Prostate Cancer Extent and Response in Human Cancer Patients
In this observational study the investigators will undertake imaging studies on men with prostate cancer. The primary hypothesis is that ultrasound spectroscopy could be used to determine the extent of disease inside and outside of the prostate gland in patients with prostate cancer. It is hoped that the changes in ultrasound backscatter parameters obtained before radical prostatectomy could be used to correlate with pathological findings from the prostate specimen after surgery.
This project is an early validation study in human subjects that will use ultrasound imaging
and spectroscopy to predict the tumour extent before treatment so that this may allow the
most appropriate treatment intervention to be individualised to patients. For examples,
patients with evidence of extra-prostatic tissue involvement may be best served with
definitive radiation therapy rather than radical prostatectomy as surgery alone in this
situation, is not optimum. Furthermore, these ultrasound parameters may be used to monitor
cell death occurring at various time points during patients' radiation treatment for prostate
cancer.
The research is exploratory since upon data analysis it will examine the use of different
ultrasound parameters as potential markers of pre-treatment tumour extent and cell death, and
correlate these with tumour shrinkage and complete pathological response. Sensitivity and
specificity values for the various ultrasound parameters will be calculated for the different
time points used and receiver-operator curves will be generated. From this data the
investigators will potentially estimate the best time-points at which to make a prediction
about patient response and the best ultrasound-spectroscopy variables to use for this
purpose.
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