Prostate Cancer Clinical Trial
Official title:
Retrospective Analysis of Endostatin Genotype in Prostate Cancer Patients to Assess the Association of a Single Nucleotide Polymorphism (D104N) in Endostatin and Prostate Cancer
RATIONALE: Studying samples of blood from patients with cancer and from healthy participants
in the laboratory may help doctors learn more about changes that may occur in DNA.
PURPOSE: This laboratory study is looking at blood samples from patients with prostate
cancer and from healthy participants to identify a polymorphism that may help in the study
of prostate cancer.
OBJECTIVES:
Primary
- Determine the incidence of the D104N COL18A1 polymorphism in patients with prostate
cancer.
Secondary
- Determine the incidence of this polymorphism in African-American patients with prostate
cancer.
OUTLINE: This is a retrospective, multicenter study.
DNA is extracted from preexisting serum samples and polymerase chain reaction is performed
to determine the genotype pattern.
PROJECTED ACCRUAL: A total of 500 patients and 250 healthy participants will be accrued for
this study.
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N/A
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