Prostate Cancer Clinical Trial
Official title:
Data Analysis for 00-C-0154, A Randomized Phase II Study of a PSA-based Vaccine in Patients With Localized Prostate Cancer Receiving Standard Radiotherapy
RATIONALE: Studying samples of blood in the laboratory from patients before and after
treatment may help doctors learn more about the effects of the treatment on cells.
PURPOSE: This clinical trial is studying samples collected from patients with localized
prostate cancer who received treatment on clinical trial NCI-00-C-0154.
OBJECTIVES:
Primary
- Evaluate the formation of antibody complexes in serum samples taken before initiation
of treatment and after completion of therapy in prostate cancer patients previously
enrolled on clinical trial NCI-00-C-0154.
- Evaluate immunologic response.
Secondary
- Clone the underlying tumor antigens discovered through SEREX.
OUTLINE: Samples previously collected on clinical trial NCI-00-C-0154 (whole blood, serum,
and peripheral mononuclear blood cells) are analyzed for immunologic responses and evidence
of formation of anti-tumor antibodies. Western blot is used to detect any evidence of
vaccine-induced autoantibody responses. If there is an indication of response, SEREX is used
to clone the underlying antigens.
;
N/A
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