Prostate Cancer Clinical Trial
Official title:
Positron Emission Tomography Imaging of Bone in Patients With Metastatic Prostate Cancer - A Pilot Study Evaluating Treatment Response
RATIONALE: Imaging procedures, such as PET scan, may help doctors predict a patient's
response to treatment and help plan the best treatment.
PURPOSE: This clinical trial is studying carbon-11 acetate and fludeoxyglucose F 18 PET scan
of the bone in patients with metastatic prostate cancer that has spread to the bone.
OBJECTIVES:
Primary
- Correlate pre-treatment and 3-month post-treatment carbon-11 (^11C) acetate and
fludeoxyglucose F 18 positron emission tomography (^18F-FDG PET) images with changes in
clinical response measures in patients with bone-dominant metastatic prostate cancer.
Secondary
- Compare ^11C acetate and ^18F-FDG PET scanning results with bone scintigraphy in these
patients to determine which best predicts clinical response.
- Correlate changes in ^11C acetate and ^18F-FDG PET with changes in prostate-specific
antigen level.
- Correlate changes in ^11C acetate and ^18F-FDG PET with clinical symptom parameters
(pain scale scores and analgesic usage scales).
- Correlate ^11C acetate and ^18F-FDG PET scan response with clinical time to
progression.
- Determine if PET scan response can predict duration of progression-free survival.
OUTLINE: This is a pilot study. Patients are stratified according to hormone response
(sensitive [stratum 1] vs refractory [stratum 2]).
Patients undergo carbon-11 acetate and fludeoxyglucose F 18 positron emission tomography
imaging prior to and 3 months after initiation of either androgen-deprivation therapy
(stratum 1) or docetaxel (stratum 2).
Pain and quality of life are assessed at baseline and at 3 months.
Patients are followed every 3 months for up to 5 years.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
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