Prostate Cancer Clinical Trial
Official title:
Androgen Blockade Therapy and Thymic Function in Individuals Over 50 Years of Age With Adenocarcinoma of the Prostate: A Cross-Sectional Study
RATIONALE: Studying changes in thymus function in patients who have been undergoing androgen
blockade therapy for prostate cancer may help doctors learn more about how well patients
will respond to treatment, may help in planning cancer treatment, and may help the study of
cancer in the future.
PURPOSE: This clinical trial is studying the effect of androgen blockade therapy on thymus
function in older patients who have undergone radical prostatectomy for localized prostate
cancer.
OBJECTIVES:
- Determine if inhibition of sex steroid action is associated with increased thymic size
in older patients who have undergone radical prostatectomy for localized adenocarcinoma
of the prostate.
- Determine if inhibition of sex steroid action is associated with an increase in the
absolute number or percentage of circulating "naive" phenotype T cells, and/or an
increase in the frequency of T-cell receptor excision circles in peripheral blood
cells.
OUTLINE: This is a nonrandomized, single-blind, cohort study. Patients are stratified
according to hormonal therapy after surgery (yes vs no).
Patients undergo CT scan of the thymus. Blood samples are analyzed by flow cytometry to
determine phenotype of T cells.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study.
;
Observational Model: Cohort, Time Perspective: Prospective
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