Prostate Cancer Clinical Trial
Official title:
MR Imaging And MR Spectroscopic Imaging Of Prostate Cancer Prior To Radical Prostatectomy: A Prospective Multi-Institutional Clinicopathological Study
RATIONALE: Imaging procedures such as magnetic resonance imaging (MRI) and magnetic
resonance spectroscopic imaging (MRSI) may improve the ability to detect the extent of
prostate cancer. It is not yet known if MRI combined with MRSI is more effective than MRI
alone in detecting the extent of prostate cancer.
PURPOSE: Diagnostic trial to compare the effectiveness of combining MRI with MRSI to that of
MRI alone in determining the extent of prostate cancer in patients who are scheduled to
undergo surgery to remove the prostate gland.
OBJECTIVES:
- Compare the accuracy of MRI vs MRI combined with magnetic resonance spectroscopic
imaging (MRSI) for the localization of prostate cancer prior to radical prostatectomy
in patients with stage I or II adenocarcinoma of the prostate.
- Compare the incremental benefit of these tests on diagnostic accuracy in these
patients.
- Compare the incremental benefit of MRSI for interobserver agreement vs MRI alone in the
localization of prostate cancer in these patients.
- Compare the accuracy of combined MRSI with that of other available information on tumor
extent derived from digital rectal exam, PSA level, Gleason score, and Partin nomogram
in these patients.
OUTLINE: This is a multicenter study.
At least 6 weeks after biopsy, patients undergo MRI and magnetic resonance spectroscopic
imaging (MRSI) over approximately 1 hour. Within 6 months of MRI/MRSI, patients undergo
radical prostatectomy.
PROJECTED ACCRUAL: A total of 134 patients will be accrued for this study within 7 months.
;
Masking: Open Label, Primary Purpose: Diagnostic
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