Prostate Cancer Clinical Trial
Official title:
A Phase II Trial of Flavopiridol in Patients With Metastatic Androgen Independent Prostate Cancer
Phase II trial to study the effectiveness of flavopiridol in treating patients with recurrent prostate cancer after hormone therapy. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
OBJECTIVES:
I. Evaluate the clinical effectiveness of flavopiridol in patients with metastatic androgen
independent adenocarcinoma of the prostate.
II. Assess the toxic effects of flavopiridol in this patient population.
OUTLINE:
Patients receive intravenous flavopiridol over 72 hours every 2 weeks for at least 4
courses. After 2 courses of treatment, patients not experiencing unacceptable toxic effects
may receive a dose escalation. Patients are followed every 3 months until death.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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