Prostate Cancer Clinical Trial
Official title:
A PROSPECTIVE MULTICENTER RANDOMIZED STUDY COMPARING STRONTIUM-89 CHLORIDE AND PALLIATIVE LOCAL FIELD RADIOTHERAPY IN PATIENTS WITH HORMONAL ESCAPED ADVANCED PROSTATIC CANCER
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and either kill them or
deliver tumor-killing substances to them without harming normal cells. This may be an
effective treatment for prostate cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of strontium or radiation
therapy in treating patients with prostate cancer that is refractory to hormone therapy who
have painful bone metastases.
OBJECTIVES: I. Compare, in a randomized Phase III setting, the subjective response rate,
time to progression, and survival of patients with hormone-refractory prostate cancer with
painful osseous metastases treated with either strontium-89 or palliative local
radiotherapy. II. Compare the quality of life achieved on these two regimens. III. Determine
the toxicity and morbidity of treatment on these two regimens. IV. Compare the cost
effectiveness of these two regimens.
OUTLINE: Randomized study. Arm I: Radioisotope therapy. Strontium-89 chloride, Strontium-89.
Arm II: Radiotherapy. Involved-field irradiation (equipment unspecified).
PROJECTED ACCRUAL: 200 patients will be entered over 2 years.
;
Primary Purpose: Treatment
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