Prostate Cancer Clinical Trial
Official title:
Development and Validation of Novel MRI Methods for the Detection of Prostate Cancer Aggressiveness
The purpose of this study is to develop, validate, and evaluate the correlation of novel magnetic resonance imaging (MRI) methods with prostate cancer aggressiveness and histological data obtained during prostatectomy.
Prostate cancer is one of the most common neoplastic diseases in men. Prostate specific
antigen (PSA) has only a limited role in the diagnosis and characterization of prostate
cancer. The diagnosis of prostate cancer is still most commonly done by transrectal
ultrasonography (TRUS) guided biopsy. However, TRUS guided biopsy carries a risk of increase
in complications. There is an increasing interest in developing more accurate non-invasive
imaging modalities which could potentially detect prostate cancer aggressiveness.
Diffusion weighted imaging (DWI) and rotating frame relaxation measurements have shown to be
particularly promising in prostate cancer detection and characterization. This study which
focuses on further development and validation of DWI and rotating frame relaxation
measurements will enroll 200 men with histologically diagnosed prostate cancer who will
undergo magnetic resonance imaging (MRI) before prostatectomy. Anatomical MRI and novel
acquisition methods focusing on DWI and rotating frame relaxation measurements will be
performed using surface coils to non-invasively detect and characterize prostate cancer.
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Observational Model: Case-Only, Time Perspective: Prospective
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