Prostate Cancer Metastatic Clinical Trial
Official title:
A Phase II Trial of Cabozantinib (XL184) in Patients With Castrate-Resistant Prostate Cancer Metastatic to Bone
The purpose of this study is to look at the effects of cabozantinib on castrate-resistant prostate cancer metastatic (cancer that has spread to other parts of the body) to the bone and to learn about any side effects caused by taking cabozantinib.
A significant proportion of patients with prostate cancer develop metastatic disease, which
most commonly affects the skeleton. Bone metastases are the cause of significant morbidity
and mortality in these patients, and require long-term management. Study participants in this
research study will have a diagnosis of castration-resistant prostate cancer metastatic to
bone.
Cabozantinib is not approved by the United States Food and Drug Administration (FDA) to treat
people for castration-resistant prostate cancer metastatic to bone or for any other type of
cancer. Giving cabozantinib to human cancer patients is experimental. Cabozantinib is
currently being given to patients on other studies. Cabozantinib is known to have anti-tumor
effects and to reduce bone metastases based on early clinical studies in prostate cancer and
other cancers. The drug is known to have side effects. The most common side effects were
fatigue, diarrhea, anorexia, rash, and palmar-plantar erythrodysesthesia (PPE) syndrome. To
date, it is not known if cabozantinib is safe and/or effective.
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