Prostate Adenocarcinoma Clinical Trial
Official title:
Evaluation of Hypoxia by PET With 18-FluoroMisonidazole During Radiation Therapy of Prostate Cancer
With functional imaging development, it becomes possible to increase radiation dose to
radioresistant areas (located inside tumor volume) using radiotherapy dose-painting. This
strategy is particularly suitable for prostate cancer where tumor hypoxia plays a major role
in the resistance of these tumors to radiation.
In order to develop intratumoral hypoxia targeting by radiotherapy dose-painting areas, we
should characterize changes in hypoxia before treatment and during radiotherapy.
- If hypoxia does not change during radiotherapy, radiotherapy dose-painting strategy by
an "integrated" boost is performed.
- If hypoxia varied (increasing or incomplete regression), a "final" boost strategy of
radiotherapy dose-painting(IMRT, stereotactic brachytherapy or high dose rate) after a
first fractionated IMRT could be considered.
This study should show that PET imaging with fluoromisonidazole (18F-MISO) is an available
tool to physicians in assessing tumor hypoxia.
n/a
Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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