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Primary Ovarian Insufficiency clinical trials

View clinical trials related to Primary Ovarian Insufficiency.

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NCT ID: NCT06117982 Recruiting - Clinical trials for Premature Ovarian Failure

The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency

Start date: October 13, 2023
Phase: Phase 2
Study type: Interventional

The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is: - Will treatment with G-CSF allow improvement in markers of ovarian reserve?

NCT ID: NCT06102655 Recruiting - Clinical trials for Traditional Chinese Medicine

Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics

JJGS and POI
Start date: July 24, 2023
Phase: Early Phase 1
Study type: Interventional

1. Identify differential metabolites in POI patients. 2. Analysis of differential metabolites and their involved mechanism pathways.

NCT ID: NCT06096766 Recruiting - Aging Clinical Trials

the Correlation Between Ovarian Function and Serum Biomarkers

Start date: October 25, 2023
Phase:
Study type: Observational

The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.

NCT ID: NCT06072794 Recruiting - Clinical trials for Diminished Ovarian Reserve

A Proof of Concept Study to Evaluate Exosomes From Human Mesenchymal Stem Cells in Women With Premature Ovarian Insufficiency (POI)

VL-POI-01
Start date: October 6, 2023
Phase: Phase 1
Study type: Interventional

The VL-POI-01 study is designed to evaluate the safety and efficacy of human placental mesenchymal stem cell derived exosome treatment in patients with premature ovarian insufficiency (POI) and diminished ovarian reserve.

NCT ID: NCT06067529 Not yet recruiting - Clinical trials for Premature Ovarian Insufficiency

A Multicenter Observational Study on the Development and Health Effects of Premature Ovarian Insufficiency

POI
Start date: November 1, 2023
Phase:
Study type: Observational

Premature ovarian insufficiency (POI) refers to the occurrence of ovarian hypofunction in women before the age of 40, which seriously affects women's overall health and quality of life. However, there is currently insufficient understanding of the risk factors, pathogenesis, short-term and long-term health effects of POI, and the health effects of the disease, and there is a lack of high-quality evidence to support clinical diagnosis and treatment decisions. This study intends to construct a hospital-based multi-center POI case-control and prospective special disease cohort, after baseline assessment and follow-up monitoring, collect disease characteristics, lifestyle, social psychology, environmental and occupational exposure, biological samples and other data, aiming to observe POI The natural occurrence, progression and health impact of POI, clarify the risk factors of POI, evaluate the impact of POI on women's health and disease risk, and discuss the benefits, risks and options of HRT for POI patients. The results of this study will deepen and expand the understanding of the occurrence and development of POI and its short-term and long-term health effects, provide high-level evidence for optimizing POI prevention, diagnosis and treatment strategies, and establish a long-term management system, laying the foundation for interventional research.

NCT ID: NCT05961371 Recruiting - Osteoporosis Clinical Trials

Strength Training for Osteoporosis Prevention During Early Menopause

STOP-EM
Start date: November 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical pilot trial is to learn about the feasibility of a high-intensity resistance training intervention in peri- and early menopausal females. The main question it aims to answer are: -Is a 9-month resistance training intervention feasible (e.g., recruitment rates, protocol adherence, attrition) Secondary aims include examining changes in bone health, muscle strength, and menopausal symptoms. Participants will participate in a 9-month progressive, supervised, resistance training intervention. Researchers will compare secondary outcomes between the exercise group and a wait-list control group.

NCT ID: NCT05890417 Recruiting - Clinical trials for Premature Ovarian Failure

Evolution of Sexual Life Quality of Women With POI Before and After Introduction of Hormone Replacement Therapy

SEX-POInt
Start date: July 17, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the evolution of quality of sex life of women with POI after introduction hormone replacement therapy through the FSFI scale

NCT ID: NCT05858307 Recruiting - Clinical trials for Polycystic Ovarian Syndrome

Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements

Start date: June 22, 2022
Phase:
Study type: Observational

This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1. To study the level of serum AMH in women with PCOS and to evaluate the utility of serum AMH in the diagnosis of PCOS. 2. To evaluate the level of serum AMH in women with POI and to evaluate the utility of serum AMH in the management of POI. 3. To evaluate the associations of basal AMH level with FSH level and AFC respectively for women undergoing ART treatment. 4. To determine the optimal regimen of gonadotropin for ovarian stimulation for women undergoing ART treatment. 5. To evaluate the predictive value of serum AMH in reproductive outcomes including oocyte quality, embryo quality, pregnancy loss, clinical pregnancy and live birth rate in women undergoing ART treatment.

NCT ID: NCT05838157 Recruiting - Clinical trials for Premature Ovarian Failure

The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age

Start date: May 4, 2023
Phase:
Study type: Observational

Cervical cancer is one of the most common cancer in women, making it the fourth largest cause of female cancer mortality worldwide. High-risk HPV types (hrHPV) continuous infection is the main cause of the premalignant and malignant lesions of the cervix. The most effective primary prevention of cervical cancer is administration HPV vaccines. There are three prophylactic HPV vaccines including bivalent HPV (2vHPV), quadrivalent HPV vaccine (4vHPV),9-valent HPV vaccine (9vHPV) currently. With the widespread of HPV vaccination, the cases related to abnormal menstrual cycle or menstrual irregularities has gradually increased in the Vaccine Adverse Event Reporting System, also the number of reports and studies were increasing. We designed this study to evaluate the statistical association of HPV vaccine and changes in menstrual cycle or menstrual irregularities、amenorrhea. And detect the signal of premature ovarian insufficiency (POI) and related events of three HPV vaccines, and to provide evidence for the safety of HPV vaccines based on the data mining and signal detection method. The research data was obtained from prospective self- developed questionnaire. Before-after study was applied in this study, investigators collect the menstrual cycle data of subjects by the questionnaire and qualitatively interview were taken. The control group is before vaccination, HPV vaccination is Intervention group.

NCT ID: NCT05740579 Recruiting - Turner Syndrome Clinical Trials

The Danish TURNER Cryopreservation Study

DANTE
Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers. Women with Turner syndrome suffer from premature ovarian insufficiency which leads to infertility and lack of estrogen. The main questions it aims to answer are: - Does the number of pregnancies and liveborn children increase after cryopreservation of ovarian tissue in turner syndrome? - Is the possible to predict when a girl with Turner syndrome reach menopause using monitoring of sex hormones? - Is it possible to identify any genes causing ovarian failure in Turner syndrome females? Participants between 2-18 years old will be asked to participate in a laparoscopic surgery and removal of one ovary in order to cryopreserve the tissue until adulthood. The the cortical tissue will be autotransplanted in order to preserve fertility. The participant will during the study period be monitored using sex hormones. Furthermore, the investigators wish to investigate the ovarian tissue using RNA sequencing and DNA methylation analysis. No comparison group is present.