Comparison of Catecholamine Concentrations in Venous Blood During

Status Recruiting

Clinical Trial Summary

To explore the relationship between perioperative blood pressure and catecholamine concentrations in adrenal venous blood and peripheral venous blood in hypertensive patients with primary aldosteronism (PA) who underwent percutaneous selective adrenal artery embolization (SAAE). In order to elucidate the related phenomena and possible mechanisms of blood pressure fluctuations caused by SAAE treatment in hypertensive patients with PA.

Clinical Trial Description

Percutaneous selective adrenal artery embolization (SAAE) is a minimally invasive interventional procedure that allows for necrosis of diseased adrenal glands by selectively embolizing the adrenal arteries supplying the lesion using an embolic agent to block the overproduction of aldosterone, and has been used as a treatment for PA as a minimally invasive alternative. However, it is of concern that in our team's SAAE practice, we have found that some patients with PA experience a dramatic increase in blood pressure during surgery, even exceeding 220/130 mmHg, yet some patients do not experience significant fluctuations in blood pressure. The perioperative risk is undoubtedly significantly increased for patients with high blood pressure fluctuations. What are the reasons for this discrepancy phenomenon? Therefore, the present study was designed to synchronize adrenal vein blood collection in PA hypertensive patients undergoing SAAE, and to compare the perioperative adrenal vein blood and peripheral venous blood catecholamine concentrations, with a view to discovering the patterns and possible causes of blood pressure fluctuations, hormone level changes, and other phenotypic changes, and elucidating the possible mechanisms of blood pressure fluctuations triggered by SAAE treatment of PA hypertension, in order to provide an evidence-based basis for minimally invasive interventional therapy for PA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06228677
Study type	Observational
Source	First Affiliated Hospital of Chengdu Medical College
Contact	Peijian Wang, PhD
Phone	028-83016145
Email	wpjmed@aliyun.com
Status	Recruiting
Phase
Start date	September 18, 2023
Completion date	December 31, 2026

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02885662` - Study of CS-3150 in Patients With Primary Aldosteronism	N/A
Withdrawn	`NCT02096939` - Microvascular Function in Primary Aldosteronism	N/A
Completed	`NCT01728493` - Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment	N/A
Recruiting	`NCT06047912` - Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone
Recruiting	`NCT04991961` - Effect of Anti-hypertensive Medications on the Diagnostic Accuracy in Screening for Primary Aldosteronism
Recruiting	`NCT05501080` - The Effect of SAAE on Ventricular Remodeling in PA Patients	N/A
Recruiting	`NCT05405101` - Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA	N/A
Recruiting	`NCT05826080` - Effect of Adrenocorticotropic Hormone Stimulation During Adrenal Vein Sampling in Primary Aldosteronism
Recruiting	`NCT05973604` - Prevalence of Primary Aldosteronism in Atrial Fibrillation
Completed	`NCT04179019` - Calcium Channel Blockade in Primary Aldosteronism	Phase 2
Completed	`NCT03500120` - Diagnostic Accuracy of Seated Saline Suppression Test for Primary Aldosteronism
Recruiting	`NCT04213963` - Prospective Study on Primary Aldosteronism in Resistant Hypertension
Completed	`NCT05435703` - Renal Cysts and Primary Aldosteronism
Recruiting	`NCT02945904` - IS Metomidate PET-CT Superior to Adrenal Venous Sampling in Predicting Outcome From Adrenalectomy in Patients With Primary Hyperaldosteronism
Enrolling by invitation	`NCT02257450` - Primary Aldosteronism in Malaysia: A Nationwide Multicentre Study	N/A
Recruiting	`NCT05561361` - The Effect of SAAE on Vascular Endothelial Function in PA Patients
Completed	`NCT03398785` - Adrenal Artery Ablation Treats Primary Aldosteronism	Phase 3
Recruiting	`NCT03224312` - Chongqing Primary Aldosteronism Study
Recruiting	`NCT04428827` - Outcome of Patients With Primary Aldosteronism
Completed	`NCT02756754` - Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms