The Prognostic Significance of Premature Ventricular Complexes in Patients Without Structural Heart Disease — PULSE  

Premature Ventricular Contraction Clinical Trial

Official title: The Prognostic Significance of Premature Ventricular Complexes in Patients Without Structural Heart Disease

Status Completed

Clinical Trial Summary

With this project the investigators aim to investigate whether premature ventricular complexes (PVC) have a prognostic significance in persons without structural heart disease. Further the investigators look at the possible connection between PVC-morphology and clinical outcome and investigate whether advanced cardiac imaging-methods may identify subtle signs of heart disease in PVC-patients with normal findings at echocardiography.

Clinical Trial Description

The PULSE project consists of four different studies:

• in study one the investigators include patients who are evaluated because of PVCs and have no signs of structural heart disease at echocardiography and exercise test. The investigators follow them (average follow-up time 3,5 years) to investigate if they have a higher mortality och cardiovascular morbidity than standard population

• in study two the investigators carry out a sub-group analysis of the population in study one to assess whether PVC:s different sites of origin (morphology) are related to the clinical outcome

• in study three the investigators include persons with a high PVC-burden (at least 10 000 PVC:s/day) and normal echocardiography. The included subjects undergo magnetic resonance (MR) to investigate whether it can identify signs of heart disease where standard echocardiography cannot ;

Related Conditions & MeSH terms

• Heart Diseases
• Premature Birth
• Premature Ventricular Complexes Multiple
• Premature Ventricular Contraction
• Ventricular Premature Complexes

• NCT number: NCT03370679
• Study type: Observational
• Source: Danderyd Hospital
• Status: Completed
• Phase: N/A
• Start date: September 2013
• Completion date: January 2018