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Premature Birth clinical trials

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NCT ID: NCT01786759 Recruiting - Preterm Infants Clinical Trials

Hepatic Function and Bile Acid in Preterm Infants Receiving Parenteral Lipids Emulsion

Start date: October 2012
Phase: Phase 4
Study type: Interventional

The etiology of parenteral nutrition-associated cholestasis(PNAC)although elusive is thought to be multifactorial, and proposed theories also include problems arising from lipid emulsions, leading us to explore alternative products available elsewhere.So we compare the different fat emulsion, and want to see if the olive oil lipid emulsions can improve hepatic tolerance in preterm infant.

NCT ID: NCT01779661 Recruiting - Cerebral Palsy Clinical Trials

Infant Aquatics Neurodevelopment Premature Infants

IA-NPI
Start date: April 2013
Phase: N/A
Study type: Interventional

The objective of this research is to examine the effect of Infant Aquatics on the development of and neurodevelopment of preterm and near-term infants, using the GM as prognostic estimation of future development. Preterm infants, a continuously growing population, are at high risk for neurodevelopment impairments ranging from minor neurological dysfunction (MND) to cerebral palsy (CP), mainly due to developmental brain injury. Infant Aquatics have been found to benefit and promote infant development. The support and sensory stimulation of the water may improve the development the sensory, motor, as well as, autonomic system of preterm infants. The study will compare intervention by Infant Aquatics to infant massage. The intervention in both methods will start at 36 weeks gestational age for 3 months and will consist of sessions with a therapist every 2 weeks. Development will be assessed and compared at 3, 8 and 18 months using Infant Motor Pattern method, Griffith developmental scales and Vineland adaptive behavior scales.

NCT ID: NCT01742533 Recruiting - Clinical trials for Premature Ovarian Failure,

Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failure

Start date: March 2012
Phase: Phase 1/Phase 2
Study type: Interventional

Premature ovarian failure (POF) refers the occurrence of amenorrhoea, elevated serum gonadotrophins and hypoestrogenism levels in female before the age of 40. It has important physical and psychological consequences/impact in those patients. Premature ovarian failure (POF) is currently managed by non-physiological sex steroid regimens which are inadequate at optimizing uterine characteristics. Human umbilical cord mesenchymal stem cells (hUCMSCs) and human cord blood mononuclear cells (hCBMNCs) have been shown to have the ability to modulate the immune response and enhance angiogenesis, suggesting the novel and promising therapeutic strategy for POF. In this study, the safety and efficacy of hUCMSCs and hCBMNCs transplantation combined with Hormone Replacement Therapy will be evaluated in patients with Premature Ovarian Failure. Participants will be followed for an expected average of 48 weeks.

NCT ID: NCT01683162 Recruiting - Preterm Infant Clinical Trials

Effects of Parenteral Nutrition With Different Lipid Emulsions in Preterm Infants

Start date: July 2012
Phase: Phase 4
Study type: Interventional

Previous studies have suggested that olive oil-based emulsion is safe and well tolerated in preterm infants, a showed efficacy and a good clinical and biological safety profile. The objective of this study was to assess the effects of a new olive-oil based lipid emulsion compared with the traditional lipid emulsions.

NCT ID: NCT01612260 Recruiting - Heart Failure Clinical Trials

Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat

Start date: September 2012
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the effects of Chinese medicine Shensong Yangxin capsule for the chronic cardiac dysfunction complicated with ventricular premature beats.

NCT ID: NCT01584323 Recruiting - Clinical trials for Preterm Premature Rupture of Membranes

Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes

Start date: April 2012
Phase: N/A
Study type: Interventional

In this study the investigators sought to determine the effects of Pomegranate (Natural pomegranate polyphenol (P. granatum L) extract) : 1. On the maternal and fetal oxidative stress and inflammation associated with PPROM. 2. On the time interval from PPROM to delivery and on fetal Ph and apger score.

NCT ID: NCT01566344 Recruiting - Heart Diseases Clinical Trials

Reversal of Cardiomyopathy by Suppression of Frequent Premature Ventricular Complexes

Start date: May 2012
Phase: N/A
Study type: Interventional

Frequent monomorphic premature ventricular complexes (PVCs) may cause a cardiomyopathy (CMP) that is reversible by suppression of the ectopic focus. This study investigates whether PVC suppression therapy can improve cardiac function and clinical condition of patients with idiopathic or ischemic CMP and frequent monomorphic PVCs. For this purpose, patients will be randomized to either one of two treatment strategies: 1) conventional heart failure therapy plus PVC suppression therapy, consisting of RFCA as primary treatment and Amiodarone as secondary treatment in case of unsuccessful RFCA, or 2) conventional heart failure therapy without PVC suppression therapy.

NCT ID: NCT01552993 Recruiting - Infant, Premature Clinical Trials

Registration and Treatment of Pain During Eye Examination of Prematurity

Start date: March 2012
Phase: N/A
Study type: Interventional

The aim of this study is to see if paracetamol has a pain-relieving effect during eye examination in premature infants.

NCT ID: NCT01518816 Recruiting - Preterm Labor Clinical Trials

Role of Serum Total Antioxidant Level in Preterm Labor

Start date: October 2011
Phase: N/A
Study type: Observational

The aim of this study is to detect the association between maternal serum antioxidant level and preterm labor.

NCT ID: NCT01482078 Recruiting - Premature Birth Clinical Trials

Magnesium for Neonatal Neuroprotection and Mothers

MnMs
Start date: January 26, 2012
Phase:
Study type: Observational

Magnesium is a treatment for mothers to protect brains of babies born early. This study investigates combined effects of magnesium and spinal or epidural anesthesia on mothers having cesareans. The investigators will use a scoring system to measure sedation and devices that subjects breath in and out of to measure breathing strength. The investigators hypothesize the combination of magnesium and anesthesia will reduce breathing strength and cause sedation. This is an observational study comparing those having magnesium and anesthesia with those just having anesthesia. Routine medical care will not be altered. Results will hopefully allow anesthesiologists to provide better patient care.