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Premature Birth clinical trials

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NCT ID: NCT04006509 Completed - Preterm Birth Clinical Trials

Prenatal Breast Pump Education of Mothers and Their Support Person

Start date: November 6, 2018
Phase: N/A
Study type: Interventional

The study will follow a prospective cohort of racially and economically diverse mothers of premature infants for 3 weeks following delivery to test whether antenatal education of the support person of mothers may decrease time to initiation of breast pumping, decrease time to lactogenesis stage II and increase breast milk production.

NCT ID: NCT04004208 Completed - Clinical trials for Retinopathy of Prematurity (ROP)

Aflibercept for Retinopathy of Prematurity - Intravitreal Injection Versus Laser Therapy

FIREFLEYE
Start date: September 25, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate how well aflibercept works in babies with ROP, comparing it with laser therapy. The study also has the objective to demonstrate how safe aflibercept is when used in babies, and describe how the drug moves into, through and out of the body.

NCT ID: NCT04004091 Completed - Premature Birth Clinical Trials

Prenatal Administration of Spermine Promotes Maturation of Premature Fetal Gut Epithelial Tight Junction: Experimental Study on Fetal Rabbit

Start date: March 1, 2019
Phase: Early Phase 1
Study type: Interventional

Infections, particularly on the gastrointestinal tract, has been known to be one of the leading causes of death in preterm infants. This is due to the immaturity of the intestinal epithelial cells. Recent studies have shown that polyamines have a role on the development of cells during embryonal phase. By this experimental study, the investigators would like to evaluate the administration of spermine on the maturation of premature fetal gut epithelial tight junction.

NCT ID: NCT04001712 Completed - Preterm Birth Clinical Trials

Effect of Early Use of Caffeine Citrate in Preterm Neonates

Start date: April 5, 2019
Phase: Phase 3
Study type: Interventional

This work is designed to study the effect of the early use of caffeine citrate in preterm neonates who need respiratory support on morbidity and short term neonatal outcome.

NCT ID: NCT03999450 Completed - Opioid Use Clinical Trials

Preventing Premature Death in Patients With Serious Opioid-related Infection

Start date: October 8, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to test the efficacy of a combination of motivational interventions and a brief therapy session to increase the adherence to medication-assisted treatment (MAT) for opioids.

NCT ID: NCT03991949 Completed - Infant Development Clinical Trials

Evaluation of Preterm Infants Fed Post-Discharge Preterm Infant Formula

Start date: October 4, 2019
Phase: N/A
Study type: Interventional

This single-group study will assess growth and tolerance of infants fed a post-discharge preterm infant formula containing a prebiotic.

NCT ID: NCT03956121 Completed - Clinical trials for Fetal Neuroprotection

Magnesium Sulfate (MgSO4) and Fetal Heart Rate (FHR) in Case of Prematurity

Start date: May 4, 2018
Phase:
Study type: Observational

Type of study: prospective descriptive monocentric study Population: 2 groups: -Exposed group: pregnant patient between 24AW+0day and 32AW+0day receiving magnesium sulfate for fetal neuroprotection in the doubt of premature delivery - Control group: pregnant patient between 32AW+1day and 35AW+0day in the same context not requiring magnesium sulfate due to their gestationnal age. Criterion(s) of judgment: Appearance of a change in short-term variability after injection of magnesium sulfate in the exposed group compared to the control group. Schedule: Inclusion from February 20 to August 31, 2018 Expected results and prospects: The general impression during my semester at the Jeanne de Flandre maternity clinic in Lille was the variability improves after injection of the magnesium sulfate used in the premature infant as a neuroprotective. The investigators would like to proove that the use of magnesium sulfate as neuroprotective in premature fetuses would improve the fetal heart rate by increasing variability. In the literature there are numerous publications on the effects of magnesium sulfate used as tocolytic (higher doses) in the threats of premature labour, generally showing a variability and number accelerations decreases without increase the number of decelerations. Is this effect is the same as the doses used for fetal neuroprotection? Expected benefits of the research: Magnesium sulfate used on premature infants for fetal neuroprotection has an impact on fetal heart rate, including variability and number of accelerations.

NCT ID: NCT03952533 Completed - Preterm Birth Clinical Trials

α-lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D and Risk Factor for Pre-term Birth

ALA
Start date: May 5, 2019
Phase: N/A
Study type: Interventional

Effects of oral administration of a food supplement constituted by α-lipoic acid, magnesium, vitamin B6 and vitamin D in tablets of 1,2 g administered daily to women presenting risk factors for preterm birth (PTB). The aim is to reduce the rate of short cervix at 19-21 weeks of gestational age and consequently reduce the occurrence of PTB.

NCT ID: NCT03950193 Completed - Premature Birth Clinical Trials

Prematurity and Parental Involvement in Child Development Care

parentpart
Start date: March 19, 2021
Phase:
Study type: Observational

The aims of the study is to evaluate the association between presence and parental participation in perinatal care and psychic development of the child at 24 months

NCT ID: NCT03945422 Completed - Clinical trials for Premature Jowl and Neck Laxity Following Facialplasty

The Use of RF in Premature Jowl and Neck Laxity Following Facialplasty

Start date: April 15, 2019
Phase: N/A
Study type: Interventional

Study is to evaluate the efficacy of treatment Radio Frequency in premature jowl and neck laxity following facialplasty