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Premature Birth clinical trials

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NCT ID: NCT02583633 Completed - Clinical trials for Managing Preterm Labor

Transdermal Nitroglycerin and Nifedipine in Preterm Labor

Start date: October 2013
Phase: Phase 4
Study type: Interventional

One of the important complications of pregnancy is preterm labor (PTL) and delivery. There are different tocolytic agents to enhance the time of delivery. The aim of this study was to compare the effect of transdermal nitroglycerin (glyceryl trinitrate, GTN) and oral nifedipine for managing preterm labor. This was a randomized clinical trial in women admitted with diagnosis of PTL. Group one have received transdermal GTN whereas group two have received oral nifedipine, vital signs, FHR, contractions, dilation and effacement as well as gestation age at the time of delivery have been monitored and evaluated in both groups of patient. Our main goal has been delay of delivery to have the most beneficial effect of primary corticosteroid administration for fetus.

NCT ID: NCT02581826 Recruiting - Clinical trials for Premature Ejaculation

Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation

Start date: October 2013
Phase: Phase 2
Study type: Interventional

The objectives of the present study aims to evaluate the safety and efficacy of Silodosin in a population of patients wih Premature Ejaculation (PE). Coupled with efficient diagnosis, it is hoped that the newer agent will improve the quality of life for patients who suffer from Premature Ejaculation (PE).

NCT ID: NCT02576418 Recruiting - Infertility Clinical Trials

PartoSure to Predict Spontaneous Preterm Delivery in Pregnancies After Assisted Reproductive Technology (ART)

Start date: October 2015
Phase: N/A
Study type: Interventional

To calculate sensitivity (SN), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) of PartoSure TTD test in predicting delivery within 7 or 14 days from testing and to compare it with cervical length (CL) measurement by transvaginal ultrasound (15 mm cut-off)

NCT ID: NCT02572037 Completed - Clinical trials for Premature Ejaculation

Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research

Start date: October 2015
Phase:
Study type: Observational

An observational study on the effect of new classification for premature ejaculation.

NCT ID: NCT02571296 Recruiting - Preterm Birth Clinical Trials

The Value of Oral Micronized Progesterone in the Prevention of Spontaneous Preterm Birth

Start date: July 2015
Phase: Phase 4
Study type: Interventional

This is a randomized, double-blind, placebo-controlled study.

NCT ID: NCT02571101 Recruiting - Clinical trials for Premature Ejaculation

A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation

Start date: November 2015
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of on-demand therapy with CDFR0812-15/25mg and CDFR0812-15/50mg compared to on-demand therapy with single-drug administration of Clomipramine HCl 15mg in Korean Male Patients Diagnosed with Premature Ejaculation

NCT ID: NCT02569216 Withdrawn - Premature Birth Clinical Trials

Electrical Inhibition (EI): A Preliminary Study To Inhibit Preterm Labor And Preterm Birth

EI
Start date: February 9, 2016
Phase: Phase 1
Study type: Interventional

An electrical-inhibition (EI) uterine pacemaker device similar to an electrical heart pacemaker delivers a weak electrical current to the human uterus during active preterm labor to rapidly and safely inhibit the unwanted premature uterine contractions and possibly a preterm birth.

NCT ID: NCT02560246 Completed - Preterm Birth Clinical Trials

Maternal Gut Microbiome (MGM) Study of Diet, the Gut Microbiome and Preterm Birth

MGM
Start date: May 4, 2015
Phase:
Study type: Observational

The purpose of this study is to determine whether diet and the gut microbiome play a role in spontaneous preterm birth (SPTB), namely delivery of the fetus prior to 37 weeks gestation.

NCT ID: NCT02557191 Terminated - Preterm Clinical Trials

Biomarkers, Neurodevelopment and Preterm Infants

Start date: April 2015
Phase:
Study type: Observational [Patient Registry]

Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders. Epidemiological studies indicate a dose-response relationship between gestational age at delivery and cognitive impairments, with the most immature of newborns being the most susceptible to developmental delays. Sensitive and reproducible biomarkers of long-term neurocognitive impairments are currently lacking. The investigators seek to identify epigenetic markers that mediate the relationship between adverse prematurity-related exposures and neurocognitive impairments. The overarching hypothesis of this proposal is that DNA methylation profiles of CD34+ hematopoetic progenitor and stem cells from very preterm infants can be used as a risk-stratifying biomarker for predicting neurocognitive impairment in childhood.

NCT ID: NCT02552927 Completed - Clinical trials for Patent Ductus Arteriosus in Premature Infants

Chest Shielding in Premature Infants During Phototherapy

SLIGHT
Start date: August 1, 2015
Phase: N/A
Study type: Interventional

This is a feasibility study where Infants will be randomized to either chest shielding with aluminum foil or chest shielding without aluminum foil while undergoing phototherapy for premature infants. The primary outcome is patent ductus arteriosus.