Pregnancy Clinical Trial
Official title:
Effects of Pregnancy on the Physico-chemical Characteristics of Cerebrospinal Acid-base Equilibrium
The third trimester of pregnancy is typically characterized by the development of a marked
respiratory alkalosis. The possible role of pregnancy-induced variations of cerebrospinal
fluid (CSF) acid-base characteristics on the development of hypocapnic alkalosis is still
unknown.
Aim of this study is to characterize, according to Stewart's approach, the acid-base
equilibrium of CSF and arterial plasma of pregnant women and compare the results with data
obtained from fertile, non-pregnant women.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | April 2019 |
Est. primary completion date | April 2019 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Pregnancy with gestational age > 35 weeks - Scheduled elective cesarean section under spinal anesthesia Exclusion Criteria: - known respiratory or neurologic disease - multiple pregnancies |
Country | Name | City | State |
---|---|---|---|
Italy | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Milan |
Lead Sponsor | Collaborator |
---|---|
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | University of Milan |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | SID PCO2 correlation | Correlation between CSF SID and PCO2 | 1 day | |
Other | Osmolality PCO2 correlation | Correlation between CSF osmolality and PCO2 | 1 day | |
Other | Plasma progesterone PCO2 correlation | Correlation between plasma progesterone concentration and plasma PCO2 | 1 day | |
Other | CSF progesterone PCO2 correlation | Correlation between CSF progesterone concentration and CSF PCO2 | 1 day | |
Primary | Strong Ion Difference | Strong Ion Difference (expressed in milliequivalents per Liter [mEq/L]) of cerebrospinal fluid and arterial plasma | 1 day | |
Secondary | Partial pressure of carbon dioxide (PCO2) | PCO2 (expressed in millimeters of Mercury [mmHg]) of cerebrospinal fluid and arterial plasma | 1 day | |
Secondary | Sum of albumin (expressed in mmol/L) and Phosphates (expressed in mmol/L) | The total amount of weak non carbonic acids, i.e. the sum of albumin and phosphates (both expressed in mmol/L) of cerebrospinal fluid and arterial plasma | 1 day | |
Secondary | Difference between cerebrospinal fluid and arterial plasma Strong Ion Difference (Delta SID) | The difference between plasma and cerebrospinal fluid SID (expressed in mEq/L) will be calculated as marker of electrolyte inbalance between these two extracellular fluid compartments. Delta SID = SIDcsf - SIDplasma | 1 day | |
Secondary | Difference between cerebrospinal fluid and arterial plasma partial pressure of CO2 (Delta PCO2) | The difference between cerebrospinal fluid and arterial plasma PCO2 (expressed in mmHg) will be calculated as a marker of acid-base equilibrium between these two extracellular fluid compartments. Delta PCO2 = SIDplasma - SIDcsf | 1 day | |
Secondary | Progesterone levels | Plasma and CSF Progesterone levels (expressed in ng/mL) will be measured | 1 day | |
Secondary | Copeptin levels | Plasma copeptin levels (expressed in pmol/L) will be measured as a marker of antidiuretic hormone activity | 1 day |
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