Pregnancy Clinical Trial
Official title:
Effects of Pregnancy on the Physico-chemical Characteristics of Cerebrospinal Acid-base Equilibrium
The third trimester of pregnancy is typically characterized by the development of a marked
respiratory alkalosis. The possible role of pregnancy-induced variations of cerebrospinal
fluid (CSF) acid-base characteristics on the development of hypocapnic alkalosis is still
unknown.
Aim of this study is to characterize, according to Stewart's approach, the acid-base
equilibrium of CSF and arterial plasma of pregnant women and compare the results with data
obtained from fertile, non-pregnant women.
The reduction in plasma PCO2 correlates with gestational age and was shown to be associated
to plasma progesterone concentrations. We hypothesize that pregnancy-related haemodilution,
inducing a reduction in CSF Strong Ion Difference (SID), might have a role in the development
of pregnancy-related hypocapnic alkalosis.
Samples of CSF and arterial plasma of pregnant women with gestational age > 35 weeks
undergoing spinal anesthesia for elective caesarean section will be analyzed for blood gases,
pH, electrolytes, osmolality, albumin and haemoglobin concentration. In addition plasma
copeptin levels will be analyzed. The same measurements will be performed in fertile,
non-pregnant women undergoing spinal anesthesia for elective surgery.
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