Pregnancy Clinical Trial
Adaptation of the maternal immune system to accommodate the semi-allogeneic fetus is necessary for pregnancy success. Dysregulation of this immune adaptation is implicated in reproductive disorders as infertility, recurrent miscarriage, fetal growth restriction, and preeclampsia. The mechanisms being responsible for fetal tolerance are not known. Several T cell subsets have been implicated in fetal tolerance. The effects of preeclampsia on memory cells are not known. The main objective of this study is to analyze the effect of preeclampsia on levels of immune cells.
| Status | Not yet recruiting |
| Enrollment | 30 |
| Est. completion date | June 2017 |
| Est. primary completion date | May 2017 |
| Accepts healthy volunteers | No |
| Gender | Female |
| Age group | 18 Years to 40 Years |
| Eligibility |
Inclusion Criteria: - healthy - written informed consent - 18-40 years Exclusion Criteria: - smoking - immune related disorders (other than preeclampsia) - fever / illness within the last month - infertility - body mass index <18 or >30 |
Observational Model: Case Control, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| University Medical Center Groningen |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Cell levels | 1 year | No |
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