Pregnancy Clinical Trial
Official title:
Pilot Study of Metformin vs. Insulin in Pregnant Overt Diabetics (MIPOD)
Many women come into pregnancy with diabetes that is controlled with either Metformin or
diet control; however, the current standard of care for the treatment of preexisting
diabetes in pregnancy is insulin. Metformin is widely used in the non-pregnant population
for glycemic control, and has been used in pregnancy for other indications without adverse
maternal or fetal outcomes. What remains unproven is the ability of Metformin to adequately
control glucose in women during pregnancy.
Our goal is to randomize 100 women who enter pregnancy with diabetes that is controlled by
either diet or an oral agent and women who are found to have an abnormal glucose challenge
test at less than 20 weeks to either standard treatment with weight based Regular and
neutral protamine Hagedorn (NPH) insulin or Metformin. Our hypothesis is that Metformin will
provide glycemic control that is equivalent to insulin in these women.
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