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NCT00324402 Clinical Trial

Plasma Brain Natriuretic Peptide Levels in Pregnancy

Pregnancy Clinical Trial

Official title:
Plasma Brain Natriuretic Peptide Levels in Pregnancy

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00324402
Other study ID # 2005008
Secondary ID
Status Completed
Phase
First received
Last updated
Start date August 2006
Est. completion date June 2008

Study information
Verified date October 2020
Source Oklahoma State University Center for Health Sciences
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.

Description:

The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date June 2008
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- women age 18 to 40

- second trimester of pregnancy

Exclusion Criteria:

- known cardiac or valvular disease,

- atrial fibrillation or other arrhythmia,

- pulmonary hypertension,

- chronic hypertension,

- hypertensive disorders of pregnancy,

- morbid obesity (BMI > 40 kg/meter squared)

- history of sleep apnea

- multiple gestation

- known renal dysfunction

- medications known to affect cardiac function

- current or past abnormal echocardiogram

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Oklahoma State University Center for Health Sciences Tulsa Oklahoma

Sponsors (1)
Lead Sponsor Collaborator
Oklahoma State University Center for Health Sciences

Country where clinical trial is conducted

United States, 

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