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Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy

Pregnancy Related Clinical Trial

Official title:
Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy

Clinical Trial Summary

The clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic in pregnant women is unique with more asymptomatic infection, higher morbidity when symptomatic, yet without a difference in mortality rate. This is strikingly different from the high mortality observed during the past influenza A pandemics. Though both influenza A virus (IAV) and SARS-CoV-2 are single-stranded RNA viruses, the exquisite vulnerability of pregnant women to influenza A but not COVID-19 remains a mystery. Our objective, therefore, is to determine the mechanisms that predispose pregnant women to severe influenza A but confer protection against SARS-CoV-2 infection by examining the viral entry factors and innate immune response mechanisms in the nasal epithelium of pregnant vs. non-pregnant age-matched women.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04962477
Study type Observational
Source Washington University School of Medicine
Contact
Status Active, not recruiting
Phase
Start date March 2, 2022
Completion date June 30, 2024
View Details
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