Pregnancy Related Clinical Trial
Official title:
TSHβX1 Splice Variant Expression and D2 Thr92Ala Polymorphism Analysis in Pregnant Women With Thyroid Diseases
Thyroid diseases are pathologies that frequently affect pregnant women causing serious complications. This current research aims to find out whether the expression of TSHβX1 splice variant and D2 Thr92Ala polymorphism in the DIO2 gene are associated with thyroid disease in Mexican pregnant women.
Deiodinase 2 (DIO2) is a selenoenzyme responsible for the deiodination of T4 to T3, which
makes it crucial for the proper functioning of thyroid hormones. Polymorphisms of DIO2 alters
the enzymatic function. In addition, the Ala92Ala genotype was reported to be related with a
reduction in the placental activity of D2, which could worsen gestational complications.
In the other hand, the TSHβ gene (NC_000001.11) located on chromosome 1 at position 38p12,
codes for the beta unit of the thyroid stimulating hormone (TSH). It is admitted that genetic
variants can show a different spectrum of actions.
This was a clinical, comparative, prospective and transversal study. Pregnant women aged
18-44 years old, were invited to identify it they had a DIO2 polymorphism or the TSHβX1
splice variant.
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