Preeclampsia Clinical Trial
Official title:
The Features of Clinical Imaging, Disease Severity and Pregnancy Outcomes in Posterior Reversible Encephalopathy Syndrome With Preeclampsia or Eclampsia
Verified date | February 2022 |
Source | Guangzhou Medical University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
Status | Completed |
Enrollment | 354 |
Est. completion date | January 31, 2022 |
Est. primary completion date | January 31, 2022 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 16 Years to 50 Years |
Eligibility | Inclusion Criteria: 1. patients were diagnosed of PRES with PE or E 2. all patients provided written informed consent Exclusion Criteria: 1. patients combined with other neurological disorders 2. patients combined with mental illness |
Country | Name | City | State |
---|---|---|---|
China | Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou |
Lead Sponsor | Collaborator |
---|---|
Dunjin Chen |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | features of clinical imaging | The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved. | Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits. | |
Primary | blood pressure(BP) | hypertension:=140/90mmHg | The BP of patients was obtained immediately at the onset of symptoms. | |
Primary | biochemical parameters | The PRES patients may have a lower level of serum albumin (?35g/L) ,and have a higher level of lactic dehydrogenase (?380U/L). | Biochemical indicators were collected within 1 week of the hospital stay. | |
Primary | pregnancy outcomes | The rates of stillbirth and premature birth (gestation less than 37 weeks) in PRES patients. | The pregnancy outcomes will record immediately when the patients deliver. | |
Primary | pregnancy outcomes | The PRES patients may have longer time of hospitalization. | From day of admission until the day of discharge or date of death from any cause,whichever came first,assessed up to 1 year. |
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