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Clinical Trial Details — Status: Suspended

Administrative data

NCT number NCT01519297
Other study ID # PP PE 2012
Secondary ID
Status Suspended
Phase N/A
First received
Last updated
Start date May 2012
Est. completion date July 2019

Study information

Verified date January 2019
Source Brigham and Women's Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will compare blood vessel and hormone differences between women who have a history of a pregnancy complicated by preeclampsia or high blood pressure, and women who have a history of uncomplicated pregnancy in the last 10 years. The investigators hypothesize that postpartum women with history of preeclampsia will have altered blood vessel function and abnormal hormone levels compared with postpartum women with history of uncomplicated pregnancy.

This study will take place over the course of 2 weeks. Each subject will be assessed on a fixed low-salt diet and a fixed high-salt diet. Subjects will have 2 non-invasive blood vessel imaging tests and fasting blood draws.


Recruitment information / eligibility

Status Suspended
Enrollment 150
Est. completion date July 2019
Est. primary completion date July 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 21 Years to 50 Years
Eligibility Inclusion Criteria:

1. Healthy female premenopausal volunteers, with regular menstrual cycles (at least 8 cycles per year)

2. Age 21 to 50 years

3. Systolic blood pressure <140 and >90 mmHg and diastolic blood pressure <90 and >60 mmHg at the screening visit

4. Body mass index < 35 kg/m2

5. History of normotensive pregnancy or history of preeclamptic or hypertensive pregnancy within the last 10 years

6. No clinically significant abnormalities on screening tests (complete blood count, serum electrolytes, liver enzymes, thyroid stimulating hormone, urinalysis, and electrocardiogram)

Exclusion Criteria:

1. Current pregnancy

2. Lactation

3. Elevated blood pressure (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg)

4. Current diagnosis of hypertension

5. Current diagnosis of diabetes mellitus

6. Personal history of coronary disease, stroke and kidney disease

7. Use of prescription medications (with the exception of stable thyroid hormone replacement dose) within 2 weeks of study

8. Use of oral contraceptives or other hormone therapy within 3 months of study;

9. Renal impairment (estimated GFR<60)

10. Active liver disease (AST, ALT, alkaline phosphatase > 1.5 times normal);

11. Current smoking, defined as smoking within the 6 months before the screening visit

12. Current or past recreational drug use

Study Design


Intervention

Drug:
Irbesartan
150mg orally for one dose

Locations

Country Name City State
United States Brigham and Women's Hospital Boston Massachusetts

Sponsors (1)

Lead Sponsor Collaborator
Brigham and Women's Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Vascular function Assess vascular function after administration of an angiotensin receptor blocker. 60 minutes
Secondary Hormonal measurements Assess hormone levels pertaining to the renin-angiotensin system after administration of irbesartan. 60 minutes
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