Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia

Preeclampsia Clinical Trial

Official title: Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia

Status Recruiting

Clinical Trial Summary

Otherwise healthy women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life. The reason why this occurs is unclear but may be related to impaired endothelial function and dysregulation of the angiotensin system that occurs during preeclampsia and persists postpartum, despite the remission of clinical symptoms. The purpose of this investigation is to determine the mechanisms contributing to this lasting blood vessel damage caused by reduced endothelial function in women who have had preeclampsia compared to women who had a healthy pregnancy. Identification of these mechanisms and treatment strategies may lead to better clinical management of cardiovascular disease risk in these women. The purpose of this study is to examine differences in the microvascular balance of angiotensin II receptors women who have had preeclampsia. This will help us better understand the mechanisms of dysregulated angiotensin II receptors in these women, and how activation or inhibition of these receptors may restore microvascular function. In this study, we use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. Using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) we examine the blood vessels in a dime-sized area of the skin.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Pre-Eclampsia
• Preeclampsia

• NCT number: NCT06157580
• Study type: Interventional
• Source: University of Iowa
• Contact: Anna Reid-Stanhewicz, PHD
• Phone: 319-467-1732
• Email: anna-stanhewicz@uiowa.edu
• Status: Recruiting
• Phase: Early Phase 1
• Start date: December 1, 2023
• Completion date: November 2024