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Metformin and Esomeprazole For Preterm Pre-eclampsia

Preeclampsia Severe Clinical Trial

Official title:
Use of Combination Metformin and Esomeprazole in Preterm Pre- Eclampsia: Randomized Controlled Trial

Clinical Trial Summary

A recent randomized controlled trial by Cluver et al included 180 women with preterm pre-eclampsia between 26+0 to 31+6 weeks' gestation undergoing expectant management: 90 were randomised to extended release metformin and 90 to placebo. Investigators found that extended release metformin (3g daily) can prolong gestation in women with preterm pre-eclampsia. Combination metformin and esomeprazole has shown promise in the treatment of preeclampsia as both agents reduce placental and endothelial secretion of soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin, and reduce endothelial dysfunction.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05232994
Study type Interventional
Source Christiana Care Health Services
Contact Marwan Ma'ayeh, MD
Phone 302-319-5680
Email maayehmarwan@gmail.com
Status Not yet recruiting
Phase Phase 1
Start date March 1, 2023
Completion date December 31, 2025
View Details
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