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Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS)

Postural Orthostatic Tachycardia Syndrome Clinical Trial

Official title:
Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1

Clinical Trial Summary

This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.

Clinical Trial Description

This comprehensive multimodality deep phenotyping will improve the diagnostic approach, inform the development of new treatments, and allow the targeting of therapies to specific POTS patients. The investigators will further identify the diagnostic tools, biomarkers, and clinical outcome measures most relevant to defining the disorder in clinical practice. The specific aim is to (1) Define clinical POTS classifications from multimodal clinical and laboratory data, (2) address exercise tolerance in POTS using metabolomic assessments, (3) evaluate novel POTS-specific patient outcome measures and (4) evaluate one year outcome data for POTS Specific research tests will include blood work (for immunophenotyping and neurohormonal assessments), autonomic function testing, skin biopsy (to evaluate intraepidermal nerve fiber density), CO (Carbon Monoxide) rebreathing (for quantitative measurement of plasma volume and red blood cell mass), patient surveys (to characterize symptom profile and disease impact). Blood biosamples will be stored as a repository for future research questions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06292104
Study type Observational [Patient Registry]
Source University of Texas Southwestern Medical Center
Contact Steve Hopkins
Phone 214-648-9275
Email steve.hopkins@utsouthwestern.edu
Status Recruiting
Phase
Start date March 5, 2024
Completion date January 2029
View Details
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